Researchers from the Photobiotechnology group at Ruhr University Bochum, in collaboration with the University of Potsdam in Germany, have developed an innovative approach to overcome challenges in green hydrogen production. The study focused on the creation of a biohybrid system by transferring the catalytic center of [FeFe]-hydrogenase, known for efficient hydrogen production, into ferredoxin, a small biomolecule acting as an electron carrier. This novel biohybrid system allows for the efficient production of hydrogen using electrons from light-powered biological systems, addressing the sensitivity of natural hydrogen-producing enzymes to oxygen. The research, published in the journal Advanced Science, simplifies the complex biocatalyst, making it more suitable for industrial applications. By replacing the natural cofactor of ferredoxin with the hydrogenase cofactor through complex synthesis pathways, the biohybrid system retains the ability to receive electrons from photosynthesis components. The successful interaction between the protein and catalyst in the biohybrid was characterized using spectroscopic and quantum-mechanical calculations, showing promising results for future sustainable hydrogen production. This study marks a significant advancement in the field of biocatalysis, offering a potential solution for the sustainable production of hydrogen as a clean energy carrier.