The leather industry in Turkey, with a notable export performance, faces environmental concerns due to waste generation and chemical usage. The high-value-added production emphasizes sustainability. Leather industry waste, including non-biodegradable materials and tanning residues, poses challenges with significant pollution. Biomass gasification emerges as a solution by converting these wastes into bioenergy, potentially reducing carbon emissions. Syngas, the primary product of gasification, can be used for fuel, heat, power generation, and potentially hydrogen production. This process contributes to controlling global temperatures within set limits. Biomass, recognized for its renewable energy potential, is crucial in decarbonizing energy systems. The European Green Deal highlights biomass for renewable energy integration. However, biomass gasification requires further exploration and optimization due to its complexity. Integrating machine learning and AI can enhance the efficiency of syngas generation, especially from waste streams like leather, offering a promising pathway for sustainable energy solutions.