The article presents a comparative study between two PV-PEM systems based on monocrystalline silicon (mono-Si) and cadmium telluride (CdTe) for hydrogen production efficiency. It emphasizes the impact of fluctuating weather conditions on the performance of these systems. Experimental results demonstrate that the CdTe PV system exhibits lower power fluctuation and higher hydrogen production under sunny weather conditions compared to the mono-Si system. However, due to the lower nominal efficiency of CdTe PV panels, the solar-to-hydrogen efficiency of CdTe PV-PEM system is slightly lower. The study highlights the importance of efficient hydrogen production systems in the context of global energy transition and the need to optimize PV technology coupled with PEM electrolyzers. While the article acknowledges the challenges of fluctuating solar energy and its impact on system durability, it also suggests that CdTe-based PV technology could offer advantages in regions with space constraints. Overall, the research points towards the significance of green hydrogen production through PEM electrolyzers as a sustainable energy solution amidst climate change and fossil fuel depletion.