A recent study published in the Journal of the American Chemical Society by a team from The University of Hong Kong and Northwestern University, led by the late Nobel Laureate Professor Fraser Stoddart, introduced RP-H200, a groundbreaking hydrogen-bonded organic framework (HOF) with exceptional porosity. Molecular crystals like HOFs have the potential for gas separation, sensing, and catalysis, but designing stable large-pore structures has been a persistent challenge. RP-H200 addresses this challenge with its mesoporous design featuring the largest pores ever reported in its class. The material's unique noncoplanar assembly using imidazole-annulated triptycene hexaacids results in a double-walled structure with honeycomb-like pores, providing an impressive surface area equivalent to one-third of a football field per gram. RP-H200 exhibits stability at high temperatures and in various solvents, making it suitable for gas storage applications. Its methane and hydrogen storage capabilities at typical conditions surpass many existing materials, with efficient adsorption mechanisms facilitating practical energy storage solutions. The material's durability is confirmed through multiple adsorption cycles, showcasing its stability in different environments. RP-H200's recyclability and solution-processability contribute to cost-effective production and sustainable energy solutions. This innovation opens doors for clean energy applications, from methane-fueled vehicle tanks to drug delivery systems, leveraging the material's large pores for diverse purposes and advancing the development of functional molecular crystals for various industries.