The Cleantech Forum Asia delved into the pivotal topic of building infrastructure for 2050, emphasizing the significance of systems thinking and innovation. The panel recognized the growing influence of artificial intelligence in infrastructure development, particularly in escalating energy demands for data centers worldwide. While challenges vary between regions like Asia and North America, a common thread is the push for efficient, sustainable infrastructure solutions. Venture capital investments are targeting microchip technologies to optimize energy efficiency in computing. Grid resilience emerged as a critical concern, with a shift towards software-defined grids capable of balancing variable energy generation and consumption. The discussion highlighted the need for intelligent, decentralized grid systems, especially in regions with weak centralized grids. Furthermore, the panel explored the evolving landscape of data centers, emphasizing the fragmentation of compute and the increasing focus on data sovereignty. The conversation expanded to include the role of molecules like hydrogen and ammonia in the energy transition. Despite volatility, there is growing interest in these alternative fuels for industrial and maritime applications. Noteworthy projects include methane pyrolysis for hydrogen production and ammonia as a decarbonization solution for the maritime sector. Amidst the drive for sustainable infrastructure, the panel also underscored the importance of designing infrastructure to cater to the needs of machines, reflecting a new era of infrastructure innovation and strategic asset planning.