A research team led by Linda Zhang at Tohoku University has made a groundbreaking advancement in the field of hydrogen isotope separation by developing a novel metal-organic framework (MOF) with exceptional selectivity. This MOF, based on a triazolate ligand and manganese ions, achieved a record-breaking D2/H2 selectivity of 32.5 at 60 K, marking a significant milestone in energy-efficient deuterium production. The material's unique mechanism leverages isotopologue-specific structural dynamics, enabling it to concentrate deuterium efficiently, even at natural abundance levels. Neutron powder diffraction experiments conducted at prestigious research institutions confirmed the MOF's two distinct adsorption sites, highlighting its practical potential for scalable and energy-efficient isotope separation systems. The MOF's practical viability, constructed from commercially available ligands and built upon a modular framework type, suggests promising prospects for future industrial integration. This project exemplifies the power of interdisciplinary collaboration, showcasing the importance of combining expertise in materials chemistry, condensed matter physics, neutron scattering, and computational modeling to reveal mechanisms of isotope-selective adsorption. The team's international collaboration involved researchers from Japan, Germany, Australia, and the United States, emphasizing the global impact and relevance of this research in advancing isotope separation technologies.