Uruguay has achieved a significant milestone in its journey towards energy sustainability by successfully transitioning a major portion of its electricity generation to renewable sources. Looking ahead, the country is now focusing on the second phase of its energy transition strategy, with green hydrogen emerging as a key element. In pursuit of this goal, the National Oil Company of Uruguay (ANCAP) has initiated a research project to assess the potential inclusion of natural hydrogen in the country's energy mix. The unique geology of Uruguay presents diverse opportunities for natural hydrogen formation, with over 30 processes identified that can lead to the generation of hydrogen in the subsurface. ANCAP's research team has pinpointed six promising exploration sites, each characterized by different geological settings and rock formations that could facilitate the production of hydrogen. One of the key sites identified is in the northwest sector of the Norte Basin, where a mafic body at depth may serve as a hydrogen source rock through serpentinization. Another site of interest is the Illescas Granite, enriched in radioactive elements, potentially generating hydrogen via radiolysis. Additional sites in the eastern part of Uruguay feature iron-rich basement rocks that could produce hydrogen through hematization. This groundbreaking study sets the stage for Uruguay's natural hydrogen exploration journey, laying the foundation for future field analyses to confirm the presence of hydrogen anomalies. By harnessing its geological diversity and advancing research in this field, Uruguay aims to further solidify its commitment to renewable energy and sustainable development.