The transportation sector, a significant contributor to carbon emissions in the United States, is moving towards zero-emission technology to combat environmental issues. Heavy-duty trucking, responsible for a large portion of emissions, faces challenges in adopting such technology due to energy and infrastructure demands. Hydrogen fuel cell technology has emerged as a promising solution for commercial fleets, offering high energy density, long-range capabilities, quick refueling, and environmental benefits. Infrastructure obstacles are being addressed through strategically placed hydrogen corridors, with a focus on demand-led development. Early adopters of hydrogen trucks report positive feedback in terms of performance, maintenance, and environmental impact. The economics of hydrogen trucking are improving through manufacturing scale, hydrogen production advancements, and infrastructure efficiency. Despite the current cost gap with diesel, the future of hydrogen trucking looks promising as costs decrease annually. Hydrogen offers a path to zero emissions without major operational changes, making it an attractive option for supply chain leaders aiming for sustainability and efficiency in their operations.