Hydrogen (H2) production from biomass and crude glycerol is explored in this study using the Aspen Plus program. Two facilities were constructed for H2 synthesis, focusing on energy efficiency through heat integration. The study examines the potential of indirect thermal integration between the facilities and employs advanced features to minimize energy consumption, specifically the recirculation oil flowrate. Noteworthy is the significant rise in H2 mole fraction in both facilities compared to previous works. The paper emphasizes the importance of clean fuel production, waste heat management, and reducing carbon emissions. The utilization of surplus crude glycerol from the biodiesel industry for H2 production is highlighted as a sustainable approach. Techniques like Pinch Analysis and Problem Table Algorithm are discussed for optimizing energy conservation in individual plants. Overall, the study accentuates the potential of hydrogen as a clean energy source and the benefits of integrating renewable sources for green H2 production.