The article discusses the growing interest in converting small organic molecules into energy and chemicals without carbon emissions as the world seeks cleaner energy systems. Traditional water electrolysis, although useful for hydrogen production, is energy-intensive due to the oxygen evolution reaction. This review by scientists from Shenzhen University and collaborating institutes highlights breakthroughs in CO₂-free electrochemical conversion systems, emphasizing the importance of material science and reaction engineering in building efficient, eco-friendly systems for sustainable energy and chemical production. The study categorizes organic feedstocks into wastewater contaminants, alcohols, alkanes, and biomass derivatives, each offering unique conversion opportunities. By replacing the oxygen evolution reaction in water splitting with selective oxidation of these organics, substantial energy savings are achieved while yielding valuable chemicals. Various electrocatalysts have been developed to facilitate these reactions, with nickel-based and cobalt- and copper-modified spinel oxides showing promising results. Advanced electrochemical devices like flow cells, membrane reactors, and solid oxide fuel cells improve mass transport and reaction control, enhancing performance. The integration of solar energy in photovoltaic-electrocatalysis systems further increases process sustainability. The technology enables high selectivity, low energy consumption, and high product yields, making industrial applications increasingly feasible. Dr. Jing-Li Luo, a co-author of the review, describes this technology as a game-changer in the field of green energy. By coupling value-added chemical production with electricity or hydrogen generation, organic waste and renewable resources can be utilized more effectively. The method has applications in wastewater treatment and on-site production of platform chemicals from biomass in the chemical industry. Despite challenges in scalability and cost, ongoing advancements in catalysts, reactor design, and process modeling indicate potential commercial viability, aligning with global carbon neutrality goals and offering a strategy for decarbonizing energy production and chemical manufacturing.