Adipic acid (AA) plays a crucial role in various industries, but traditional production methods result in environmental pollution, leading to a shift towards renewable AA production. Recent progress in metabolic engineering has highlighted the potential of catalytic hydrogenation of cis,cis-muconic acid (CCMA) for AA synthesis. While significant achievements have been made in catalyst screening and characterization, challenges such as the use of precious metals, low substrate solubility, and inefficient reactors persist. In response, Ni/Al2O3 catalysts have been developed, achieving a remarkable 99.9% AA yield at high substrate concentrations. This breakthrough offers a sustainable and cost-effective alternative for industrial AA production, showcasing the potential of green chemistry and renewable energy in the field.