Direct methanol fuel cells (DMFCs) have gained attention for their ability to convert chemical energy into electricity using methanol. However, the widely used Nafion membranes in DMFCs have issues with methanol crossover, affecting performance. Scientists have explored integrating nanoporous graphene through plasma treatment between Nafion membranes to address this challenge. The study shows that this integration significantly enhances proton conductivity and methanol selectivity, leading to improved DMFC performance. By creating precise nanopores and functional groups on graphene, the team achieved high proton conductivity while maintaining excellent selectivity. The research demonstrates that plasma etching is a convenient and scalable method for producing nanoporous graphene, offering potential for developing more efficient proton exchange membranes (PEMs) in DMFCs. When tested in DMFC assemblies, the integrated nanoporous graphene increased proton conductivity, methanol selectivity, open-circuit voltage (OCV), and power density. The results indicate a promising direction for enhancing the performance of DMFCs through innovative materials and scalable manufacturing processes.