The article introduces a groundbreaking approach to tackle the stability and efficiency challenges in seawater electrolysis by employing a novel high-entropy alloy (HEA) catalyst, HEA-NFCCM/Ti@S. This catalyst showcases remarkable catalytic activity for the Oxygen Evolution Reaction (OER) and integrates a unique combination of nickel, iron, cobalt, chromium, manganese, and sulfur, leveraging the high-entropy effect and sluggish diffusion to enhance performance and structural stability. By forming a sulfate anion layer and a Cr-induced Lewis acid layer on the catalyst surface, the HEA-NFCCM/Ti@S effectively mitigates chloride ion corrosion, demonstrating exceptional durability in natural seawater conditions. The research highlights the potential of HEAs as a cost-effective and adaptable alternative to noble metal catalysts, paving the way for efficient and sustainable hydrogen production from seawater resources. This paradigm-shifting approach combines corrosion resistance with enhanced catalytic performance, marking a significant advancement in anode catalysts for natural seawater electrolysis and offering a promising solution for large-scale hydrogen production.